Potassium Carbonate → Dimethyl 4-{3-[4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl]propyl}phthalate

HRID 970840Notes

Reaction equation

HRID 970840 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][C:12]2[CH:13]=[C:14]([C:22]([O:24][CH3:25])=[O:23])[C:15](=[CH:20][CH:21]=2)[C:16]([O:18][CH3:19])=[O:17])[CH:5]=[CH:6][C:7]=1[OH:8].C(=O)([O-])[O-].[K+].[K+].Br[CH2:33][C:34](=[O:39])[C:35]([CH3:38])([CH3:37])[CH3:36]>>[CH3:36][C:35]([CH3:38])([CH3:37])[C:34](=[O:39])[CH2:33][O:8][C:7]1[CH:6]=[CH:5][C:4]([CH2:9][CH2:10][CH2:11][C:12]2[CH:13]=[C:14]([C:22]([O:24][CH3:25])=[O:23])[C:15](=[CH:20][CH:21]=2)[C:16]([O:18][CH3:19])=[O:17])=[CH:3][C:2]=1[CH3:1]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 21642BromopinacoloneHCID 17983061HCID 17983061, compound

Product 1

HCID 17983003Dimethyl 4-{3-[4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl]propyl}phthalate

Procedure

In a manner similar to Example 1g, by reacting 900 mg (2.6 mmol) of dimethyl 4-[3-(3-methyl-4-hydroxyphenyl)propyl]phthalate with 400 mg (2.9 mmol) of potassium carbonate and 390 μl (2.9 mmol) of 1-bromopinacolone. A colorless oil is obtained (m=910 mg; y=79%).

Workup

  1. customA colorless oil is obtained (m=910 mg; y=79%)

Sources & evidence

ORD record
ord-0cd8fa063f6f4ef38c8aae301f58178a
Source dataset
uspto-grants-2007_12
Patent number
US07312249B2

Reaction notes

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