反应详情

2.9 ml of phosphorus oxychloride are added slowly to 7 ml of N,N-dimethylformamide in a nitrogen atmosphere (formylation solution). 5 g (0.029 mol) of methyl indole-7-carboxylate are dissolved in 7 ml of DMF and added slowly to the formylation solution, during which the temperature does not rise above 30 degrees. The mixture is then warmed at 100° for one hour. After cooling, the mixture is poured into water and neutralised using sodium hydroxide solution, and the deposited crystals are filtered off with suction. m.p. 154°. Yield 5.3 g (89.9% of theory).

1. additionadded slowly to the formylation solution, during which the temperature
2. customdoes not rise above 30 degrees
3. temperatureThe mixture is then warmed at 100° for one hour
4. temperatureAfter cooling
5. filtrationthe deposited crystals are filtered off with suction