Potassium Carbonate → HCID 69224807, compound

HRID 971193Notes

Reaction equation

HRID 971193 reaction equation
[Cl:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[C:12]([C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23]2[C:24]3[CH2:32][CH2:31][NH:30][CH2:29][C:25]=3[N:26]=[CH:27][N:28]=2)=[CH:18][CH:17]=1)([CH3:15])([CH3:14])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[ClH:1].[C:12]([C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23]2[C:24]3[CH2:32][CH2:31][N:30]([C:2]4[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=4)[CH2:29][C:25]=3[N:26]=[CH:27][N:28]=2)=[CH:18][CH:17]=1)([CH3:15])([CH3:13])[CH3:14]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 59021490N-(4-tert-butylphenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine

Product 1

HCID 69224807HCID 69224807, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared using the general procedure set forth in Example 3, above, by heating a mixture of 2-chloro-3-(trifluoromethyl)pyridine (0.108 g, 0.59 mmol), N-(4-tert-butylphenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine (0.112 g, 0.40 mmol) and potassium carbonate (0.16 g, 1.19 mmol) in DMF (2 mL) for 1 h.

Workup

  1. temperatureabove, by heating

Sources & evidence

ORD record
ord-ba9601c82b634efe83f4ad41d520e7f0
Source dataset
uspto-grants-2007_12
Patent number
US07312330B2

Reaction notes

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