Potassium Carbonate → (4-tert-Butyl-phenyl)-[2-methoxymethyl-7-(3-trifluoromethyl-pyridin-2-yl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amine hydrochloride

HRID 971197Notes

Reaction equation

HRID 971197 reaction equation
[Cl:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[C:12]([C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23]2[C:24]3[CH2:35][CH2:34][NH:33][CH2:32][C:25]=3[N:26]=[C:27]([CH2:29][O:30][CH3:31])[N:28]=2)=[CH:18][CH:17]=1)([CH3:15])([CH3:14])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[ClH:1].[C:12]([C:16]1[CH:17]=[CH:18][C:19]([NH:22][C:23]2[C:24]3[CH2:35][CH2:34][N:33]([C:2]4[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=4)[CH2:32][C:25]=3[N:26]=[C:27]([CH2:29][O:30][CH3:31])[N:28]=2)=[CH:20][CH:21]=1)([CH3:15])([CH3:13])[CH3:14]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 59021476N-(4-tert-butylphenyl)-5,6,7,8-tetrahydro-2-(methoxymethyl)pyrido[3,4-d]pyrimidin-4-amine

Product 1

HCID 69224501(4-tert-Butyl-phenyl)-[2-methoxymethyl-7-(3-trifluoromethyl-pyridin-2-yl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-yl]-amine hydrochloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared using the general procedure set forth in Example 5 using 2-chloro-3-(trifluoromethyl)pyridine (0.084 g, 0.46 mmol), N-(4-tert-butylphenyl)-5,6,7,8-tetrahydro-2-(methoxymethyl)pyrido[3,4-d]pyrimidin-4-amine (0.101 g, 0.31 mmol), potassium carbonate (0.128 g, 0.93 mmol) in DMF (2 mL). The title compound was obtained as a light yellow solid after formation and isolation of its hydrochloride salt.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-842aef261bca4bfd92e2e8f2cc0b09d6
Source dataset
uspto-grants-2007_12
Patent number
US07312330B2

Reaction notes

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