HCID 59021554, compound → HCID 59021465, compound

HRID 971207Notes

Reaction equation

HRID 971207 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[C:13]3[CH2:28][CH2:27][N:26](CC4C=CC=CC=4)[CH2:25][C:14]=3[N:15]=[C:16]([CH2:18][N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[N:17]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[OH-].[OH-].[Pd+2]>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[C:13]3[CH2:28][CH2:27][NH:26][CH2:25][C:14]=3[N:15]=[C:16]([CH2:18][N:19]3[CH2:20][CH2:21][O:22][CH2:23][CH2:24]3)[N:17]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 59021554HCID 59021554, compound

Product 1

HCID 59021465HCID 59021465, compoundYield 77.1%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

A catalytic amount palladium hydroxide on carbon powder (20% Pd moisture ea. 60%) was added to a solution of N-(4-tert-butylphenyl)-7-benzyl-5,6,7,8-tetrahydro-2-(morpholinomethyl)pyrido[3,4-d]pyrimidin-4-amine (240 mg, 0.51 mmol) in methanol and was stirred under a hydrogen filled balloon over night at room temperature. Reaction solution was filtered through celite and filtrate was concentrated to yield the product as a white powder (150 mg).

Workup

  1. customReaction solution
  2. filtrationwas filtered through celite and filtrate
  3. concentrationwas concentrated

Sources & evidence

ORD record
ord-b6758ac16eea47c8b90092ec63013a6a
Source dataset
uspto-grants-2007_12
Patent number
US07312330B2

Reaction notes

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