反应详情

温度

70 °C

To a solution of sodium ethoxide prepared by heating 5.5 g. of sodium in 200 ml. of ethanol at 70° C. is added 17 g. of 7-chloro-3-hydrazono-oxindole over a period of 3.5 hours, and the resulting solution is heated at 70° C. for 24 hours. The solvent is evaporated in vacuo, the residue dissolved in water, acidified with 6 N. hydrochloric acid and the resulting precipitate recovered by filtering, washed three times with water, dried by suction and crystallized from methylene chloride/ether to obtain 7-chlorooxindole, 218°-220° C.

1. temperatureby heating 5.5 g
2. customThe solvent is evaporated in vacuo
3. dissolutionthe residue dissolved in water
4. customhydrochloric acid and the resulting precipitate recovered
5. filtrationby filtering
6. washwashed three times with water
7. customdried by suction
8. customcrystallized from methylene chloride/ether