Hydrochloric Acid → N-Methyl-N'-hydroxy-N"-[4-(4-imidazolyl)butyl]guanidine dihydrochloride

HRID 971432Notes

Reaction equation

[CH3:1][NH:2][C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[N:11]=[CH:12][NH:13][CH:14]=1)=S.[ClH:15].CNC(=NCCCCC1N=CNC=1)SC.[NH2:31][OH:32]>>[ClH:15].[ClH:15].[CH3:1][NH:2][C:3]([NH:31][OH:32])=[N:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[N:11]=[CH:12][NH:13][CH:14]=1

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 787Hydroxylamine

HCID 178484951N,S-dimethyl-N'-[4-(4-imidazolyl)butyl]isothiourea

HCID 178486108N-[4-(1H-imidazol-5-yl)butyl]-N'-methylcarbamimidothioic acid

Product 1

HCID 178484950N-Methyl-N'-hydroxy-N"-[4-(4-imidazolyl)butyl]guanidine dihydrochloride

Procedure

When N-methyl-N'-[4-(4-imidazolyl)butyl]thiourea is reacted with methanolic hydrogen chloride by the procedure of Example 1(i) the product is N,S-dimethyl-N'-[4-(4-imidazolyl)butyl]isothiourea which on treatment with hydroxylamine by the procedure of Example 1(ii) gives the title product.

Sources & evidence

ORD record: ord-4fb4ecb83df94b33abd977e285cedb06
Source dataset: uspto-grants-1979_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04160030

Reaction notes

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