Morpholine → HCID 70504214, compound

HRID 971516Notes

Reaction equation

HRID 971516 reaction equation
OC(=CC([O-])=O)C.CS(Cl)(=O)=O.[CH2:13]([C:20]1[S:26][CH:25]2[CH:22]([C:23](=[O:48])[N:24]2[C:27](=[C:41](OS(C)(=O)=O)[CH3:42])[C:28]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][C:35]([N+:38]([O-:40])=[O:39])=[CH:34][CH:33]=2)=[O:29])[N:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[NH:49]1[CH2:54][CH2:53][O:52][CH2:51][CH2:50]1>O1CCCC1.C(N(CC)CC)C>[CH2:13]([C:20]1[S:26][CH:25]2[CH:22]([C:23](=[O:48])[N:24]2[C:27](=[C:41]([N:49]2[CH2:54][CH2:53][O:52][CH2:51][CH2:50]2)[CH3:42])[C:28]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][C:35]([N+:38]([O-:40])=[O:39])=[CH:34][CH:33]=2)=[O:29])[N:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

7

Reactant 4

HCID 8083MorpholineHCID 31297Methanesulfonyl chlorideHCID 86735547HCID 86735547, compoundHCID 178468087HCID 178468087, compound

Product 1

HCID 70504214HCID 70504214, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolvent3×HCID 8471TriethylamineSolvent

Procedure

One suspends p-nitrobenzyl α-[3-benzyl-7-oxoethylidene)-2,6-diaza-4-thiabicyclo[3,2,0]hept-2-en-6-yl]-α-(1-hydroxyethylideneacetate (2.265 g) in anhydrous tetrahydrofuran (30 ml), adds dropwise a solution of triethylamine (1.11 g) and methanesulfonyl chloride (630 mg) in tetrahydrofuran (2 ml) at 1° to 2° C., and stirs for 25 minutes. To the produced solution of p-nitrobenzyl α-[3-benzyl-7-oxo-2,6-diaza-4-thiabicyclo[3,2,0]hept-2-en-6-yl]-α-(1-methanesulfonyloxyethylidene)acetate, one adds a solution of morpholine (480 mg) in tetrahydrofuran (2 ml), and stirs for 15 minutes to give a solution of p-nitrobenzyl α-[3-benzyl-7-oxo-2,6-diaza-4-thiabicyclo[3,2,0]hept-2-en-6-yl]-α-(1-morpholinoethylidene)acetate, cools to -20° C., adds pyridine (396 mg) and a solution of bromine in carbon tetrachloride (1 mole/liter: 5 ml), pours into diluted hydrochloric acid after 15 minutes, and extracts with ethyl acetate. The extract solution is washed with water, dried over magnesium sulfate, and evaporated. Purification of the obtained residue by chromatography over silica gel (50 g), from the fraction eluted with a mixture of benzene containing 10% ethyl acetate gives p-nitrobenzyl α-[3-benzyl-7-oxo-2,6-diaza-4-thiabicyclo[3,2,0]hept-2-en-6-yl]-α(2-bromo-1-morpholinoethylidene)acetate (2.36 g). Yield: 78%.

Sources & evidence

ORD record
ord-c7d4edad941b4637ba2f2ec68a2b90ee
Source dataset
uspto-grants-1979_07
Patent number
US04160085

Reaction notes

Loading…