Hydrochloric Acid → HCID 36689053, compound

HRID 971550Notes

Reaction equation

HRID 971550 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:7]([NH:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4].Cl>CO.[Pd]>[NH2:1][C@H:2]([C:7]([NH:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131709976HCID 131709976, compound

Product 1

HCID 36689053HCID 36689053, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3.36 g of Z-Ile-Gly-OMe are dissolved in 100 ml of methanol and 10 ml of 1 N hydrochloric acid and hydrogenated in the presence of 0.5 g of Pd on charcoal (10%). After filtering off the catalyst the solvent is completely evaporated. The resulting foam is homogeneous in a thin layer chromatogram on silica gel; Rf = 0.26 in chloroform-methanol (95:5).

Workup

  1. filtrationAfter filtering off the catalyst the solvent
  2. customis completely evaporated

Sources & evidence

ORD record
ord-523a5ec09d394c9da1ad4cac392646df
Source dataset
uspto-grants-1979_07
Patent number
US04159981

Reaction notes

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