HCID 20518157, compound → HCID 20518134, compound

HRID 971611Notes

Reaction equation

HRID 971611 reaction equation
C([N:8]([CH2:22][CH:23](O)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[Br:30])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17]C)=[C:13]([O:19]C)[C:12]=1[Cl:21])C1C=CC=CC=1>Br>[BrH:30].[Cl:21][C:12]1[C:11]2[CH2:10][CH2:9][NH:8][CH2:22][CH:23]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[Br:30])[C:16]=2[CH:15]=[C:14]([OH:17])[C:13]=1[OH:19]

Participants

3

Reactant 1

HCID 20518157HCID 20518157, compound

Product 1

HCID 20518134HCID 20518134, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

A solution of 4.0 g of the above hydrochloride in 250 ml of 48% hydrobromic acid is stirred and refluxed for two hours. The reaction mixture is evaporated in vacuo to yield 6-chloro-1-(2-bromophenyl)-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide.

Workup

  1. temperaturerefluxed for two hours
  2. customThe reaction mixture is evaporated in vacuo

Sources & evidence

ORD record
ord-7c0a5596156c455381eb4e7718e71170
Source dataset
uspto-grants-1979_07
Patent number
US04160765

Reaction notes

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