反应详情

A mixture of 12 parts of 1-(4-methoxyphenyl)-5-phenyl-1H-imidazole-2-thiol, 10 parts of Raney-nickel catalyst, 160 parts of ethanol, 180 parts of ethyl acetate and 36 parts of ammonium hydroxide is stirred and refluxed overnight. The solution is decanted and the residual Raney-nickel is boiled again in a mixture of 160 parts of ethanol and 180 parts of ethyl acetate. The solvent is decanted. The combined ethanol/ethyl acetate phases are evaporated. The residue is crystallized from a mixture of 2-propanol and water. The product is filtered off and dried, yielding 6.5 parts (61%) of 1-(4-methoxyphenyl)-5-phenyl-1H-imidazole; mp. 105.7° C.

1. temperaturerefluxed overnight
2. customThe solution is decanted
3. additionthe residual Raney-nickel is boiled again in a mixture of 160 parts of ethanol and 180 parts of ethyl acetate
4. customThe solvent is decanted
5. customThe combined ethanol/ethyl acetate phases are evaporated
6. customThe residue is crystallized from a mixture of 2-propanol and water
7. filtrationThe product is filtered off
8. customdried