Allyl bromide → HCID 54453186, compound

HRID 971854Notes

Reaction equation

HRID 971854 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:18][CH2:17][CH2:16][NH:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH2:26](Br)[CH:27]=[CH2:28]>C1(C)C=CC=CC=1>[CH2:28]([N:15]1[CH2:16][CH2:17][CH2:18][CH:14]1[C:11]1[CH:12]=[CH:13][C:8]([O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[CH:9][CH:10]=1)[CH:27]=[CH2:26]

Participants

5

Reactant 3

HCID 7841Allyl bromideHCID 8471TriethylamineHCID 457897032-(4-Phenoxyphenyl)pyrrolidine

Product 1

HCID 54453186HCID 54453186, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

8 parts of 2-(4-phenoxyphenyl) pyrrolidine, 3.3 parts of triethylamine, 4 parts of allyl bromide and 70 parts of toluene were refluxed for 5 hours. After cooling and filtration, there were obtained by distillation 7.7 parts of 1-allyl-2-(4-phenoxyphenyl) pyrrolidine, B.P./0.2 mm Hg: 148°-150° C., nD26 =1.5695, M.P. of its acid fumarate: 115°-116° C. (isopropanol/ether).

Workup

  1. temperatureAfter cooling
  2. filtrationfiltration

Sources & evidence

ORD record
ord-ed544bd13edd4592956ee4582d6811cb
Source dataset
uspto-grants-1979_07
Patent number
US04161529

Reaction notes

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