Acetyl chloride → HCID 54180656, compound

HRID 971855Notes

Reaction equation

HRID 971855 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:18][CH2:17][CH2:16][NH:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:26](Cl)(=[O:28])[CH3:27]>CCOCC>[C:26]([N:15]1[CH2:16][CH2:17][CH2:18][CH:14]1[C:11]1[CH:12]=[CH:13][C:8]([O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[CH:9][CH:10]=1)(=[O:28])[CH3:27]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 457897032-(4-Phenoxyphenyl)pyrrolidine

Product 1

HCID 54180656HCID 54180656, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of 10 parts of 2-(4-phenoxyphenyl) pyrrolidine in 200 parts of anhydrous ether and 4.2 parts of triethylamine, there was added a solution of 3.3 parts of acetyl chloride in 30 parts of ether. The reflux was maintained for one hour, then the reaction mixture was filtered off on cooling and the filtrate was distilled. There were obtained 13 parts of 1-acetyl-2-(4-phenoxyphenyl) pyrrolidine.

Workup

  1. temperatureThe reflux was maintained for one hour
  2. filtrationthe reaction mixture was filtered off
  3. temperatureon cooling
  4. distillationthe filtrate was distilled

Sources & evidence

ORD record
ord-b2b2ae106a2141feaa536b7007d7f4ab
Source dataset
uspto-grants-1979_07
Patent number
US04161529

Reaction notes

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