反应详情

温度

50 °C

To a mixture of 9.6 g of 50% sodium hydride and 200 ml of dimethyl formamide was added dropwise 34 g of ethyl 2-cyclohexanone carboxylate under ice-cooling, the mixture was stirred at 50° C. for 30 minutes, thereafter again under ice-cooling 45.3 g of ethyl 2-(p-chloromethylphenyl)propionate was added dropwise, and the mixture was heated at 50°-60° C. with stirring for 1 hour. After the reaction was completed, the reaction mixture was poured into an ice-water, extracted with ether, the extract washed with water, dried over anhydrous sodium sulfate, and the solvent removed by distillation to give 69.5 g of an oily substance, which was subjected to a vacuum distillation affording 57 g of the dsired compound as a colorless oily substance, b.p. 200°-205° C. at 0.4 mm Hg.

1. temperaturecooling
2. additionwas added dropwise
3. temperaturethe mixture was heated at 50°-60° C.
4. stirringwith stirring for 1 hour
5. extractionextracted with ether
6. washthe extract washed with water
7. dry with materialdried over anhydrous sodium sulfate
8. customthe solvent removed by distillation
9. customto give 69.5 g of an oily substance, which
10. distillationwas subjected to a vacuum distillation