反应详情

温度

50 °C

A mixture of 256.3 g of 5ethyl-5-methylhydantoin (1.805 mols), 675 ml of dimethylformamide and 4.51 g of lithium chloride is stirred at 50° C. 288.0 g of propene oxide (4.96 mols) are slowly added dropwise over the course of 2 hours. Thereafter the temperature is gradually raised to 90° C. over the course of 10 hours. The reaction mixture is brought to pH = 7 with 4 drops of 2 N hydrochloric acid, filtered and concentrated on a rotational evaporator at 90° C. bath temperature, under a waterpumpvacuum. It is then treated at 90° C. under 0.1 mm Hg until the weight remains constant. 465 g of a clear pale yellow product (99.5% of theory) are obtained.

1. temperatureThereafter the temperature is gradually raised to 90° C. over the course of 10 hours
2. filtrationfiltered
3. concentrationconcentrated on a rotational evaporator at 90° C. bath temperature
4. additionIt is then treated at 90° C. under 0.1 mm Hg until the weight