6-Methyluracil → HCID 21312564, compound

HRID 971924Notes

Reaction equation

HRID 971924 reaction equation
[CH3:1][C:2]1[NH:7][C:6](=[O:8])[NH:5][C:4](=[O:9])[CH:3]=1.Cl[CH2:11][CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15]>CN(C)C=O>[CH3:17][O:16][C:14]([CH2:13][CH2:12][CH2:11][N:7]1[C:2]([CH3:1])=[CH:3][C:4](=[O:9])[N:5]([CH2:11][CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])[C:6]1=[O:8])=[O:15]

Participants

4

Reactant 2

HCID 122836-MethyluracilHCID 76612Butanoic acid, 4-chloro-, methyl ester

Product 1

HCID 21312564HCID 21312564, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

40.4 g (0.2 mol) of the dipotassium salt of 6-methyluracil and 57.4 g (0.42 mol) of methyl 4-chlorobutyrate are stirred in 350 ml of dimethylformamide for 10 hours at 125° C. The mixture is filtered and the clear solution is concentrated to dryness, 48.2 g of the desired crude product being obtained as a yellowish semi-solid mass (73.8% of theory).

Workup

  1. filtrationThe mixture is filtered
  2. concentrationthe clear solution is concentrated to dryness, 48.2 g of the desired crude product
  3. custombeing obtained as a yellowish semi-solid mass (73.8% of theory)

Sources & evidence

ORD record
ord-7f19e482e844481aa1048bbce20ccda0
Source dataset
uspto-grants-1979_07
Patent number
US04161603

Reaction notes

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