反应详情

A solution of dimethyl trans-2-(3-hydroxy-1-octenyl)cyclopropane-1,1-dicarboxylate (22.4 g), described in Example 42, dihydropyran (80 ml, distilled over sodium) and p-toluenesulfonic acid monohydrate (300 mg) is allowed to stand at room temperature for 30 min. After adding a few ml of 10% Na2CO3 solution the mixture is extracted with ether. The ether extract is washed with water, dried (Na2SO4) and evaporated. Purification of the residue by chromatography on silica gel gives the title compound.

1. extractionis extracted with ether
2. extractionThe ether extract
3. washis washed with water
4. dry with materialdried (Na2SO4)
5. customevaporated
6. customPurification of the residue by chromatography on silica gel