反应详情

To N-(5-benzylaminohexyl)-N-methylaniline (3.06 g= 10 mmol) and 3.48 g (10 mmol) 2-benzyloxy-5-(bromoacetyl)benzamide in 35 ml dimethylformamide, add 2.70 g (20 mmol) K2CO3. Stir 20 hrs. and pour into 150 ml water. Allow the gum to settle, decant, and dissolve the gum in ether. Extract with 1.0 N HCl, and then neutralize into NaHCO3 and extract with EtOAc. Dry, concentrate, and dissolve the oil in 50 ml ethanol. Add 0.3 g (8 mmol) NaBH4, stir 20 hrs., and concentrate. Partition between EtOAc and 1.0 N NaHCO3. Dry and concentrate to give a yellow foam.

1. customdecant
2. dissolutiondissolve the gum in ether
3. extractionExtract with 1.0 N HCl
4. extractionextract with EtOAc
5. customDry
6. concentrationconcentrate
7. dissolutiondissolve the oil in 50 ml ethanol
8. stirringstir 20 hrs
9. concentration, and concentrate
10. customPartition between EtOAc and 1.0 N NaHCO3
11. customDry
12. concentrationconcentrate
13. customto give a yellow foam