1-Chloro-4-iodobenzene → 1-(4'-chlorophenyl)-5-methyl-2-(1H)-pyridone

HRID 972310Notes

Reaction equation

HRID 972310 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.[Cl:9][C:10]1[CH:15]=[CH:14][C:13](I)=[CH:12][CH:11]=1>>[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([N:6]2[CH:7]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]2=[O:8])=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 125101-Chloro-4-iodobenzeneHCID 704822-Hydroxy-5-methylpyridine

Product 1

HCID 98592781-(4'-chlorophenyl)-5-methyl-2-(1H)-pyridoneYield 75%

Procedure

The reaction of 5-methyl-2-(1H)-pyridone and 1-chloro-4-iodobenzene (Aldrich Chemical Company) in the procedure of Example 1 yields 1-(4'-chlorophenyl)-5-methyl-2-(1H)-pyridone as a white crystalline solid in 75% yield.

Sources & evidence

ORD record
ord-b107b95b356340e7a6473ec50bc7997f
Source dataset
uspto-grants-1977_10
Patent number
US04052509

Reaction notes

Loading…