Potassium Hydroxide → HCID 54273563, compound

HRID 972356Notes

Reaction equation

HRID 972356 reaction equation
[OH-:1].[K+].[F:3][C:4]1[CH:9]=[C:8]([CH:10]([CH3:15])[C:11](OC)=[O:12])[CH:7]=[CH:6][C:5]=1[C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=1[F:23].Cl.[NH2:25]O>CO.O>[F:3][C:4]1[CH:9]=[C:8]([CH:10]([CH3:15])[C:11]([NH:25][OH:1])=[O:12])[CH:7]=[CH:6][C:5]=1[C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=1[F:23]

Participants

6

Reactant 3

HCID 14797Potassium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 21406791HCID 21406791, compound

Product 1

HCID 54273563HCID 54273563, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Procedure

Potassium hydroxide (1.0 g.) in methanol (20 ml.) was added dropwise to a solution of methyl 2-(2,2',4'-trifluoro-4-biphenylyl)propionate (0.42 g.) and hydroxylamine hydrochloride (0.5 g.) in methanol (10 ml.) until the solution was just alkaline to limits. After standing overnight at room temperature the filtrate from inorganic salts was evaported to small bulk, diluted with water, washed with ether, acidified with dilute hydrochloric acid, re-extracted with ether, washed with ether, dried and evaporated to dryness. The residue was racrystallised from benzene to give 2-(2,2',4'-trifluoro-4-biphenylyl) propionhydroxamic acid, m.p. 148°-150° C. (decomp.)

Workup

  1. washwashed with ether
  2. extractionre-extracted with ether
  3. washwashed with ether
  4. customdried
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-34339d05b4fd4a94bafb63d8ecf6192b
Source dataset
uspto-grants-1977_10
Patent number
US04052514

Reaction notes

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