Dimethylformamide → HCID 21404528, compound

HRID 972696Notes

Reaction equation

HRID 972696 reaction equation
[CH3:1][NH:2][C:3]1[CH:4]=[C:5]([C:9]2[NH:10][C:11](=[O:18])[C:12](=[CH:16][CH:17]=2)C(O)=O)[CH:6]=[CH:7][CH:8]=1.CN(C)C=O.[CH2:24]([Cl:26])[Cl:25]>O=S(Cl)Cl>[ClH:25].[CH3:1][NH:2][C:3]1[CH:4]=[C:5]([C:9]2[NH:10][C:11](=[O:18])[C:12](=[CH:16][CH:17]=2)[CH2:24][Cl:26])[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 21404525HCID 21404525, compound

Product 1

HCID 21404528HCID 21404528, compound

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideCatalyst

Procedure

6-[m-(Methylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid (1.0 g.) is added to 10 ml. of SOCl2 containing 10 drops of dimethylformamide. Solution soon occurred, and after about 15 minutes, a new solid starts to appear. The mixture is diluted with methylene chloride, and the 6-[m-(methylamino)phenyl]-1,2-dihydro-2-oxonicotinyl chloride hydrochloride collected and washed with methylene chloride.

Workup

  1. customthe 6-[m-(methylamino)phenyl]-1,2-dihydro-2-oxonicotinyl chloride hydrochloride collected
  2. washwashed with methylene chloride

Sources & evidence

ORD record
ord-9a66cf1b085b48d3a8818ba3f09ef986
Source dataset
uspto-grants-1977_10
Patent number
US04053470

Reaction notes

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