Dimethylformamide → HCID 21404571, compound

HRID 972697Notes

Reaction equation

HRID 972697 reaction equation
[CH2:1]([NH:4][C:5]1[CH:6]=[C:7]([C:11]2[NH:12][C:13](=[O:20])[C:14](=[CH:18][CH:19]=2)C(O)=O)[CH:8]=[CH:9][CH:10]=1)[CH2:2][CH3:3].CN(C)C=O.[CH2:26]([Cl:28])[Cl:27]>S(Cl)(Cl)=O>[ClH:27].[CH2:1]([NH:4][C:5]1[CH:6]=[C:7]([C:11]2[NH:12][C:13](=[O:20])[C:14](=[CH:18][CH:19]=2)[CH2:26][Cl:28])[CH:8]=[CH:9][CH:10]=1)[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 21404552HCID 21404552, compound

Product 1

HCID 21404571HCID 21404571, compound

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideCatalyst

Procedure

6-[m-(Propylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid (1.0 g.) is added to 10 ml. thionyl chloride containing 10 drops of dimethylformamide. Solution soon occurs and after a half hour a new solid appears. The mixture is diluted with methylene chloride and the 6-[m-(propylamino)phenyl]-1,2-dihydro-2-oxonicotinyl chloride hydrochloride collected and washed with methylene chloride.

Workup

  1. waitSolution soon occurs and after a half hour
  2. customthe 6-[m-(propylamino)phenyl]-1,2-dihydro-2-oxonicotinyl chloride hydrochloride collected
  3. washwashed with methylene chloride

Sources & evidence

ORD record
ord-5d53b255f26245b29ccd56581e3a854a
Source dataset
uspto-grants-1977_10
Patent number
US04053470

Reaction notes

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