Chloride → HCID 21404600, compound

HRID 972698Notes

Reaction equation

HRID 972698 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:14]2[NH:15][C:16](=[O:23])[C:17](=[CH:21][CH:22]=2)[C:18](O)=O)[CH2:4][CH2:3]1.[Cl-:24]>ClCCl>[ClH:24].[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:14]2[NH:15][C:16](=[O:23])[C:17](=[CH:21][CH:22]=2)[CH2:18][Cl:24])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 312ChlorideHCID 21404546HCID 21404546, compound

Product 1

HCID 21404600HCID 21404600, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 3.44 g. of finely divided 6-[o-(4-methyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinic acid and 35 ml. of thionly chloride is stirred at room temperature for 16 hours, then diluted with 150 ml. of dichloromethane. The resulting solution is evaporated at reduced pressure and the resulting precipitate of 6-[o-(4-methyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinyl chloride hydrochloride is collected by filtration, washed with dichloromethane and dried.

Workup

  1. additionA mixture of 3.44 g
  2. additiondiluted with 150 ml
  3. customThe resulting solution is evaporated at reduced pressure
  4. filtrationthe resulting precipitate of 6-[o-(4-methyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinyl chloride hydrochloride is collected by filtration
  5. washwashed with dichloromethane
  6. customdried

Sources & evidence

ORD record
ord-0ae815e419a74456a71bba01ac6b2de9
Source dataset
uspto-grants-1977_10
Patent number
US04053470

Reaction notes

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