1-Phenylpiperazine → HCID 21405119, compound

HRID 972735Notes

Reaction equation

HRID 972735 reaction equation
Cl[CH2:2][C:3]([C:5]1[N:6]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[F:18])[CH:7]=[CH:8][CH:9]=1)=[O:4].[C:19]1([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(N(CC)CC)C>CO>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][N:6]2[CH:7]=[CH:8][CH:9]=[C:5]2[C:3](=[O:4])[CH2:2][N:28]2[CH2:29][CH2:30][N:25]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:26][CH2:27]2)=[C:12]([F:18])[CH:13]=1

Participants

5

Reactant 3

HCID 70961-PhenylpiperazineHCID 8471TriethylamineHCID 20391514HCID 20391514, compound

Product 1

HCID 21405119HCID 21405119, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-chloroacetyl-1-(4-chloro-2-fluorobenzyl)pyrrole, N-phenylpiperazine and triethylamine in methanol is treated by the procedure described in Example 1b to produce 1-(4-chloro-2-fluorobenzyl)-2-[α-(4-phenylpiperazino)acetyl]pyrrole.

Workup

  1. additionis treated by the procedure

Sources & evidence

ORD record
ord-d6ae61ffeb684ce48a383bb8c83f736c
Source dataset
uspto-grants-1977_10
Patent number
US04053599

Reaction notes

Loading…