Hydrazine hydrate (1:1) → HCID 20309456, compound

HRID 972776Notes

Reaction equation

HRID 972776 reaction equation
[C:1]([NH:5][CH2:6][CH:7]([OH:26])[CH2:8][O:9][C:10]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=1[C:18]1[N:23]=[N:22][C:21](OC)=[CH:20][CH:19]=1)([CH3:4])([CH3:3])[CH3:2].O.[NH2:28][NH2:29]>>[C:1]([NH:5][CH2:6][CH:7]([OH:26])[CH2:8][O:9][C:10]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=1[C:18]1[N:23]=[N:22][C:21]([NH:28][NH2:29])=[CH:20][CH:19]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21246153HCID 21246153, compound

Product 1

HCID 20309456HCID 20309456, compound

Procedure

A stirred mixture of 6-[2-(3-t-butylamino-2-hydroxypropoxy)-4-methoxyphenyl]-3-methoxypyridazine (0.36 g, 0.001 mole) and hydrazine hydrate (8 ml) was heated under reflux for 2 hours. Excess of hydrazine hydrate was removed under reduced pressure and 6-[2-(3-t-butylamino-2-hydroxypropoxy)-4-methoxyphenyl]-3-hydrazino pyridazine was isolated by crystallisation from ethanol-ether

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. customExcess of hydrazine hydrate was removed under reduced pressure

Sources & evidence

ORD record
ord-0ea10db522644be19d4c187124d42608
Source dataset
uspto-grants-1977_10
Patent number
US04053601

Reaction notes

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