Hydroxylamine → 1-(2-thienylmethyl)piperidin-4-amine(SALTDATA: 2HCl)

HRID 972826Notes

Reaction equation

HRID 972826 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][N:7]1[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]1.[NH2:14]O.[Al]>[OH-].[Na+].[Ni]>[NH2:14][CH:10]1[CH2:11][CH2:12][N:7]([CH2:6][C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)[CH2:8][CH2:9]1

Participants

6

Reactant 3

HCID 787HydroxylamineHCID 5359268AluminumHCID 1800183741661-54-5

Product 1

HCID 172216381-(2-thienylmethyl)piperidin-4-amine(SALTDATA: 2HCl)

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 14798Sodium HydroxideSolvent

Procedure

N-(2-Thienylmethyl)-4-piperidone is reacted with hydroxylamine, followed by nickel, aluminium alloy in 30% sodium hydroxide solution, in a similar manner to that described in Example 19 to give 4-amino-N-(2-thienylmethyl)piperidine.

Sources & evidence

ORD record
ord-9faeccc2585945bda1439939a089684e
Source dataset
uspto-grants-1977_10
Patent number
US04053615

Reaction notes

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