Hydrochloric Acid → HCID 18006462, compound

HRID 972839Notes

Reaction equation

HRID 972839 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:11](NN)=[O:12])[NH:6]2.CC1C=CC(S(Cl)(=O)=O)=CC=1.Cl>N1C=CC=CC=1>[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:11]=[O:12])[NH:6]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 73974-Toluenesulfonyl chlorideHCID 68118038HCID 68118038, compound

Product 1

HCID 18006462HCID 18006462, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

23.0 g 4-methylindole-2-carboxylic acid hydrazide were added in small portions, while stirring and during ice cooling, to the solution of 23.0 g p-toluene sulfochloride in 300 ml pyridine. Then it was stirred for another hour in the ice bath and for another hour at room temperature, poured onto a mixture of 350 ml concentrated hydrochloric acid and ice, the precipitated 4-methylindole-2-carboxylic acid-(N'-tosyl-hydrazide) filtered off with suction and thoroughly washed with well diluted hydrochloric acid, then with water.

Workup

  1. filtrationthe precipitated 4-methylindole-2-carboxylic acid-(N'-tosyl-hydrazide) filtered off with suction
  2. washthoroughly washed with well diluted hydrochloric acid

Sources & evidence

ORD record
ord-b4ebcb4a68764375b17ccb26aa78366b
Source dataset
uspto-grants-1977_10
Patent number
US04053624

Reaction notes

Loading…