Water → HCID 21405485, compound

HRID 972875Notes

Reaction equation

HRID 972875 reaction equation
Cl.[NH2:2][CH:3]([CH2:7][C:8]([O:10][CH3:11])=[O:9])[C:4]([OH:6])=[O:5].[N+:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21]Cl)([O-:14])=[O:13].O.C(=O)([O-])[O-].[K+].[K+]>O1CCCC1>[N+:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21][NH:2][CH:3]([CH2:7][C:8]([O:10][CH3:11])=[O:9])[C:4]([OH:6])=[O:5])([O-:14])=[O:13]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 243192-Nitrobenzenesulfenyl chlorideHCID 128327472-Amino-4-methoxy-4-oxobutanoic acid hydrochloride

Product 1

HCID 21405485HCID 21405485, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

9.2 g (50 millimoles) of DL-2-amino-3-methoxycarbonyl-propionic acid hydrochloride (i.e., DL-aspartic acid O62 -methyl ester HCl), 10.5 g of o-nitrophenylsulfenyl chloride, 50 ml of water, 70 ml of tetrahydrofuran and 24.3 g of potassium carbonate are treated in the same manner as described in Example 1-(1). 9.8 g of DL-2-(o-nitrophenylsulfenylamino)-3-methoxycarbonyl-propionic acid are obtained. M.p. 108°- 109° C.

Sources & evidence

ORD record
ord-590fa15591664bf0836553fc3b34e1d9
Source dataset
uspto-grants-1977_10
Patent number
US04053609

Reaction notes

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