Diethanolamine → HCID 21402099, compound

HRID 973210Notes

Reaction equation

HRID 973210 reaction equation
[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10]1[N:19]=[C:18](Cl)[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1.[NH:21]([CH2:25][CH2:26][OH:27])[CH2:22][CH2:23][OH:24]>CN(C)C=O>[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10]1[N:19]=[C:18]([O:24][CH2:23][CH2:22][NH:21][CH2:25][CH2:26][OH:27])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1

Participants

4

Reactant 2

HCID 8113DiethanolamineHCID 214020964-Chloro-2-(1-methyl-5-nitro-1H-imidazol-2-yl)quinazoline

Product 1

HCID 21402099HCID 21402099, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A suspension of 4 g of 2-(1-methyl-5-nitro-2-imidazolyl)-4-chloroquinazolin and 1.6 g of diethanolamine in 25 ml of dimethyl formamide is heated at 100° C for 11/2 hours. After cooling, the resulting crystals are filtered off, washed with tetrahydrofuran and water, and dried to obtain the heading compound, m.p. 236°-239° C.

Workup

  1. temperatureAfter cooling
  2. filtrationthe resulting crystals are filtered off
  3. washwashed with tetrahydrofuran and water
  4. customdried
  5. customto obtain the heading compound, m.p. 236°-239° C.

Sources & evidence

ORD record
ord-4499435bcb8e41e688a631be11613170
Source dataset
uspto-grants-1977_10
Patent number
US04055642

Reaction notes

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