3,6-Difluorophthalic anhydride → HCID 19989311, compound

HRID 973357Notes

Reaction equation

HRID 973357 reaction equation
[F:1][C:2]1[CH:12]=[CH:11][C:10]([F:13])=[C:4]2C(O[C:8](=O)[C:3]=12)=O>[Cu]=O.CN1C(=O)CCC1>[F:13][C:10]1[CH:4]=[CH:3][C:2]([F:1])=[CH:12][C:8]=1[C:3]1[CH:4]=[C:10]([F:13])[CH:11]=[CH:12][C:2]=1[F:1]

Participants

4

Reactant 1

HCID 5139183,6-Difluorophthalic anhydride

Product 1

HCID 19989311HCID 19989311, compound

Reagents, catalysts & solvents 2

HCID 14829Copper oxideCatalystHCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
150 °C

Procedure

Using the procedure above, 0.5 g of 3,6-difluorophthalic anhydride, 0.1 g of copper (II) oxide and 10 mL of NMP were combined and heated to 150° C. for 12 h. GCMS analysis of the reaction mixture indicated complete consumption of the starting material and formation of 1,4-difluorobenzene as the major product. A small amount of 2,2',5,5'-tetrafluorobiphenyl was formed as a by-product.

Workup

  1. customconsumption of the starting material and formation of 1,4-difluorobenzene as the major product

Sources & evidence

ORD record
ord-2a6e6658319d4c50af47513d1055c83d
Source dataset
uspto-grants-1991_11
Patent number
USH0000992

Reaction notes

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