Dimethylformamide → HCID 15079120, compound

HRID 973398Notes

Reaction equation

HRID 973398 reaction equation
[SH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:13]([CH3:19])[CH2:14][C:15](=[O:18])[NH:16][N:17]=3)=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:20]N(C)C=O.CI>C(N(CC)CC)C>[CH3:19][CH:13]1[C:12]([C:8]2[CH:7]=[C:6]3[C:11]([C:2]([S:1][CH3:20])=[N:3][CH:4]=[N:5]3)=[CH:10][CH:9]=2)=[N:17][NH:16][C:15](=[O:18])[CH2:14]1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 178429554HCID 178429554, compound

Product 1

HCID 15079120HCID 15079120, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To 0.36 g of Compound 56 obtained in Example 18 were added 10 ml of dimethylformamide, 0.2 ml of triethylamine and 0.1 ml of methyl iodide. The resulting mixture was stirred at room temperature for 30 minutes and then concentrated. Thereafter, water was added to the residue, and the crystals precipitated were collected by filtration and dried to give 0.3 g (79%) of 4,5-dihydro-5-methyl-6-(4-methylthioquinazolin-7-yl)-3(2H)-pyridazinone (Compound 57).

Workup

  1. concentrationconcentrated
  2. additionThereafter, water was added to the residue
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-6e5b7ba42c084bfbaf27b0244466546c
Source dataset
uspto-grants-1991_11
Patent number
US05063227

Reaction notes

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