Methylamine → HCID 15079190, compound

HRID 973401Notes

Reaction equation

HRID 973401 reaction equation
[CH3:1][CH:2]1[C:7]([C:8]2[CH:17]=[C:16]3[C:11]([C:12](SC)=[N:13][C:14]([S:18][CH3:19])=[N:15]3)=[CH:10][CH:9]=2)=[N:6][NH:5][C:4](=[O:22])[CH2:3]1.[CH3:23][NH2:24]>CO>[CH3:1][CH:2]1[C:7]([C:8]2[CH:17]=[C:16]3[C:11]([C:12]([NH:24][CH3:23])=[N:13][C:14]([S:18][CH3:19])=[N:15]3)=[CH:10][CH:9]=2)=[N:6][NH:5][C:4](=[O:22])[CH2:3]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 15079189HCID 15079189, compound

Product 1

HCID 15079190HCID 15079190, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

In 50 ml of 40% methylamine solution in methanol was suspended 0.40 g of Compound 59 obtained in Example 61. The suspension was stirred at 60° C. for 3 hours and then concentrated. Thereafter, water was added to the residue, and the crystals precipitated were collected by filtration and dried to give 0.34 g (89%) of 4,5-dihydro-5-methyl-6-(4-methylamino-2-methylthioquinazolin-7-yl)-3(2H)-pyridazinone (Compound 60).

Workup

  1. concentrationconcentrated
  2. additionThereafter, water was added to the residue
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-50d537f27c4b4335958ecf34805caea3
Source dataset
uspto-grants-1991_11
Patent number
US05063227

Reaction notes

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