反应详情

A mixture of 10 g of 3-mercapto-4-methoxyphenylacetone, 9 g of anhydrous potassium carbonate, 42 g of methyl iodide, and 50 ml of methyl ethyl ketone was stirred under refluxing for 20 hours, and after cooling, the reaction mixture was filtered. The filtrate obtained was, then, evaporated to dryness. The residue formed was dissolved in ethyl acetate and after washing the solution obtained with water, ethyl acetate was distilled off and the crude crystals obtained were recrystallized from a mixture of n-hexane and ether to provide 9 g of 3-methylthio-4-methoxyphenylacetone having a melting point of 74°-75° C.

1. temperatureunder refluxing for 20 hours
2. temperatureafter cooling
3. filtrationthe reaction mixture was filtered
4. customThe filtrate obtained
5. customevaporated to dryness
6. customThe residue formed
7. washafter washing the solution
8. customobtained with water, ethyl acetate
9. distillationwas distilled off
10. customthe crude crystals obtained
11. customwere recrystallized from a mixture of n-hexane and ether