反应详情

3.3 ml (3.3 mmol) of 1 M tetrabutylammonium fluoride solution in tetrahydrofuran is added to a solution of 1.5 g (3.3 mmol) of the compound from Example 1 in 15 ml of absolute tetrahydrofuran and the mixture is stirred at room temperature for 1 hour. Saturated sodium hydrogencarbonate solution is then added to the reaction solution and it is extracted several times with methylene chloride. The combined organic phases are dried (MgSO4), concentrated and then filtered through silica gel.

1. extractionis extracted several times with methylene chloride
2. dry with materialThe combined organic phases are dried (MgSO4)
3. concentrationconcentrated
4. filtrationfiltered through silica gel