Water → HCID 19988903, compound

HRID 973678Notes

Reaction equation

HRID 973678 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]1[N:17]=[C:16]([CH2:18][OH:19])[CH:15]=[N:14]1.[H-].[Na+].[CH3:22]I.O>O1CCCC1>[Cl:12][C:4]1[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=[C:2]([Cl:1])[C:3]=1[N:13]1[N:17]=[C:16]([CH2:18][O:19][CH3:22])[CH:15]=[N:14]1

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 19988890HCID 19988890, compound

Product 1

HCID 19988903HCID 19988903, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of [2-(2,6-dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-yl]methanol (1.5 g), sodium hydride (0.15 g) and methyl iodide (0.7 g) in tetrahydrofuran (30 ml) was stirred at room temperature for 2 hours and left over the weekend. The mixture was added to water and extracted with ether. The extract was worked up to give 2-(2,6-dichloro-4-trifluoromethylphenyl)-4-methoxymethyl-2H-1,2,3-triazole, m.p. 32°-33°. (Compound 20)

Workup

  1. waitleft over the weekend
  2. extractionextracted with ether

Sources & evidence

ORD record
ord-62ba2a60521c453e8dd836bd810a9727
Source dataset
uspto-grants-1991_11
Patent number
US05064844

Reaction notes

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