Water → HCID 19988888, compound

HRID 973679Notes

Reaction equation

HRID 973679 reaction equation
Br[CH2:2][C:3]1[CH:7]=[N:6][N:5]([C:8]2[C:13]([Cl:14])=[CH:12][C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=2[Cl:19])[N:4]=1.[CH2:20]([SH:22])[CH3:21].[H-].[Na+].O>O1CCCC1>[Cl:19][C:9]1[CH:10]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:12]=[C:13]([Cl:14])[C:8]=1[N:5]1[N:4]=[C:3]([CH2:2][S:22][CH2:20][CH3:21])[CH:7]=[N:6]1

Participants

6

Reactant 4

HCID 962WaterHCID 6343EthanethiolHCID 24758Sodium hydrideHCID 19778339HCID 19778339, compound

Product 1

HCID 19988888HCID 19988888, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-Bromomethyl-2-(2,6-dichloro-4-trifluoromethylphenyl) 2H-1,2,3-triazole (2.9 g) was added portionwise to a stirred mixture of ethanethiol (0.5 g) and sodium hydride (0.25 g) in tetrahydrofuran (30 ml) and the mixture stirred at room temperature for 3 hours. The mixture was added to water and extracted with ether. The extract was worked up to give 2-(2,6-dichloro-4-trifluoromethylphenyl)-4-(ethylthiomethyl)-2H-1,2,3-triazole, m.p. 53°-54°. (Compound 19)

Workup

  1. extractionextracted with ether

Sources & evidence

ORD record
ord-793bf7f76abf4553b86d54594b61dd7c
Source dataset
uspto-grants-1991_11
Patent number
US05064844

Reaction notes

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