Hydrochloric Acid → HCID 19989034, compound

HRID 973718Notes

Reaction equation

HRID 973718 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]1[C:15](=[O:28])[O:16][C:17]2[C:22]([CH:23]=1)=[CH:21][CH:20]=[C:19]([O:24][C:25](=[O:27])[CH3:26])[CH:18]=2)=O)(C)(C)C.[ClH:29]>C(O)C>[ClH:29].[C:25]([O:24][C:19]1[CH:18]=[C:17]2[C:22]([CH:23]=[C:14]([NH:13][CH2:12][CH2:11][CH2:10][CH2:9][NH2:8])[C:15](=[O:28])[O:16]2)=[CH:21][CH:20]=1)(=[O:27])[CH3:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14878740HCID 14878740, compound

Product 1

HCID 19989034HCID 19989034, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 19.85 g of the product of Step B in 200 ml of ethanol and 38.1 ml of ethanolic 2N hydrogen chloride was refluxed with stirring for one hour and was then evaporated to dryness to obtain 18.67 g of raw product melting at 90° C. The product was crystallized from a refluxing mixture of 95-5 acetonitrile and water and was vacuum filtered. The product was empasted with isopropyl ether to obtain 8.44 g of the desired product melting at 160° C.

Workup

  1. temperaturewas refluxed
  2. customwas then evaporated to dryness
  3. customto obtain 18.67 g of raw product melting at 90° C
  4. customThe product was crystallized from a refluxing mixture of 95-5 acetonitrile and water
  5. filtrationfiltered

Sources & evidence

ORD record
ord-de0ce718ffea41bd8d2b1334e3a51db9
Source dataset
uspto-grants-1991_11
Patent number
US05064861

Reaction notes

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