Water → HCID 178486068, compound

HRID 973725Notes

Reaction equation

HRID 973725 reaction equation
[C:1]([O:8]C([O-])=O)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=O.S(O)(O)(=O)=O.[CH3:17][NH:18][C:19](=[NH:21])[SH:20].[C:22](=[O:25])(O)[O-:23].[Na+].O>C(Cl)Cl>[C:4]([O:23][C:22]([N:18]([CH3:17])[C:19](=[N:21][C:1]([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:8])[SH:20])=[O:25])([CH3:7])([CH3:6])[CH3:5]

Participants

6

Reactant 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 22064466Tert-butyldicarbonateHCID 178485225HCID 178485225, compound

Product 1

HCID 178486068HCID 178486068, compoundYield 69.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

58.1 g of tert-butyl dicarbonate, 25.3 g of methyl thioisourea sulfate, 50 g of sodium bicarbonate, 500 ml of water and 500 ml of methylene chloride were stirred for 48 hours at 20° C. and after decanting, followed by extraction with methylene chloride and evaporation to dryness, 27 g of the expected product melting at 118° C. were obtained.

Workup

  1. customafter decanting
  2. extractionfollowed by extraction with methylene chloride and evaporation to dryness

Sources & evidence

ORD record
ord-d3b96d5f31fd4049abe5ac4a9ae2cf38
Source dataset
uspto-grants-1991_11
Patent number
US05064861

Reaction notes

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