Water → HCID 54346887, compound

HRID 973739Notes

Reaction equation

HRID 973739 reaction equation
Br[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[F:8][C:9]([F:22])([F:21])[C:10]1[CH:11]=[CH:12][C:13]([CH:17]([CH3:20])[CH2:18][CH3:19])=[C:14]([OH:16])[CH:15]=1.C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O>[F:8][C:9]([F:21])([F:22])[C:10]1[CH:11]=[CH:12][C:13]([CH:17]([CH3:20])[CH2:18][CH3:19])=[C:14]([CH:15]=1)[O:16][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

6

Reactant 4

HCID 962WaterHCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 19989035HCID 19989035, compound

Product 1

HCID 54346887HCID 54346887, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
80 °C

Procedure

2.5 ml of ethyl bromoacetate were added to 4 g of the product of Step C in 15 ml of dimethylsulfoxide and 4 g of potassium carbonate were added, followed by heating at 80° C. for 2 hours 30 minutes. The reaction medium was poured into iced water and extracted with methylene chloride. The extracts were dried and concentrated to dryness to obtain 5.10 g of the expected product.

Workup

  1. additionwere added
  2. extractionextracted with methylene chloride
  3. customThe extracts were dried
  4. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-cc43f31632b04414a90af92024ee4d9e
Source dataset
uspto-grants-1991_11
Patent number
US05064861

Reaction notes

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