反应详情

Then, 20 mg sodium was reacted in 3 ml n-propanol. The solution was cooled with an ice bath and 209 mg of the above product (S)-2,7-dihydro-7-phenyl-2-(phenylmethyl)-5-chloro-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine was added with stirring. After 1 hour the reaction was poured into 100 ml saturated NaCl solution and extracted with 200 ml CHCl3. The organic layer was dried over MgSO4, filtered and concentrated to yield an oil which was purified by radial chromatography (5-10% MeOH/ CHCl3, 2 mm plate) to yield 168 mg of (S)-2,7-dihydro-7-phenyl-2-(phenylmethyl)-5-propoxy-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine (75%).

1. temperatureThe solution was cooled with an ice bath
2. extractionextracted with 200 ml CHCl3
3. dry with materialThe organic layer was dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated
6. customto yield an oil which
7. customwas purified by radial chromatography (5-10% MeOH/ CHCl3, 2 mm plate)