Dimethylformamide → HCID 178499052, compound

HRID 973838Notes

Reaction equation

HRID 973838 reaction equation
C[C:2]([CH2:4][C:5]([O:7]CC)=O)=[S:3].[NH2:10][C:11]1[N:15]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[NH:13][N:12]=1.[CH3:20]N(C)C=O>>[OH:7][C:5]1[CH:4]=[C:2]([S:3][CH3:20])[N:12]2[N:13]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[N:15]=[C:11]2[N:10]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 77201Methyl 5-amino-1H-1,2,4-triazole-3-carboxylateHCID 11744773Butanoic acid, 3-thioxo-, ethyl ester

Product 1

HCID 178499052HCID 178499052, compound

Procedure

A suspension of ethyl 2-methylthiocarbonylacetate (37.6 g) and 3-amino-5-methoxycarbonyl-s-triazole (20 g) in dimethylformamide (200 ml) was refluxed for one hour. After removing the solvent by distillation under reduced pressure, ether was added to the residue, and the formed crystals were purified by silica gel chromatography, giving 11.7 g of the objective compound.

Workup

  1. temperaturewas refluxed for one hour
  2. customAfter removing the solvent
  3. distillationby distillation under reduced pressure, ether
  4. additionwas added to the residue
  5. customthe formed crystals were purified by silica gel chromatography

Sources & evidence

ORD record
ord-e8f6ed2b3c85490084d93feb9ece9d92
Source dataset
uspto-grants-1991_11
Patent number
US05064953

Reaction notes

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