Urea → 1-benzyl-1-methylurea

HRID 974032Notes

Reaction equation

HRID 974032 reaction equation
[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH2:10][C:11](N)=[O:12]>>[CH3:1][N:2]([CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:11]([NH2:10])=[O:12]

Participants

3

Reactant 2

HCID 1176UreaHCID 7669N-Methylbenzylamine

Product 1

HCID 156760161-benzyl-1-methylureaYield 75%

Conditions

Temperature
118 °C

Procedure

To N-methylbenzylamine (12.1 g, 0.1 mol) was added urea (6.0 g, 0.1 mol). After stirred at 118° C. for 4 h, the mixture was cooled to room temperature. The solidified mixture was ground to a powder, washed with n-hexane and recrystallized with ethyl acetate to afford N-methyl-N-benzylurea (12.3 g, 75% yield): mp 125°-129° C.

Workup

  1. temperaturethe mixture was cooled to room temperature
  2. washwashed with n-hexane
  3. customrecrystallized with ethyl acetate

Sources & evidence

ORD record
ord-f25c5d27b3c34b84b63b0a8cccb05e2d
Source dataset
uspto-grants-1991_11
Patent number
US05066666

Reaction notes

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