Phenethylamine → 3-[(2-phenylethyl)amino]propanenitrile

HRID 974150Notes

Reaction equation

HRID 974150 reaction equation
[C:1](#[N:4])[CH:2]=[CH2:3].[CH2:5]([CH2:12][NH2:13])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(O)C>[CH2:5]([CH2:12][NH:13][CH2:3][CH2:2][C:1]#[N:4])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 1001PhenethylamineHCID 7855Acrylonitrile

Product 1

HCID 31553093-[(2-phenylethyl)amino]propanenitrile

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.3 g of acrylonitrile are added dropwise to a solution of 12.1 g of N-benzylmethylamine in 20 ml of ethanol. The reaction mixture is stirred for three hours at room temperature and then concentrated under vacuum to give 17 g (Y=97%) of the expected product.

Workup

  1. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-9603e5dde5fc48b2bca3abb3095c79f5
Source dataset
uspto-grants-1991_11
Patent number
US05068064

Reaction notes

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