Chloroacetonitrile → (4-Benzylpiperidin-1-yl)acetonitrile

HRID 974151Notes

Reaction equation

HRID 974151 reaction equation
[CH2:1]([N:3](CC)CC)[CH3:2].ClCC#N.[CH2:12]([CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1(C)C=CC=CC=1>[CH2:12]([CH:19]1[CH2:24][CH2:23][N:22]([CH2:2][C:1]#[N:3])[CH2:21][CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 7856ChloroacetonitrileHCID 8471TriethylamineHCID 317384-Benzylpiperidine

Product 1

HCID 10680164(4-Benzylpiperidin-1-yl)acetonitrile

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

40.8 ml of triethylamine and 22.2 g of chloroacetonitrile are dissolved in 180 ml of toluene, and 51.6 g of 4-benzylpiperidine are then added dropwise all at once.

Sources & evidence

ORD record
ord-395d55e3a4ac4cca974c1bb33955e569
Source dataset
uspto-grants-1991_11
Patent number
US05068064

Reaction notes

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