反应详情

2.45 g of the product of Step 1, 36 ml of methylene chloride, 47 ml of 0.5N sodium bicarbonate solution and 3.40 g of metachloroperbenzoic acid were stirred at 20° C. for 5 hours. 0.7 g of per-acid and 9.30 ml of bicarbonate solution were added after 2 hours. After decanting, extraction was done with methylene chloride and the extracts were washed with water, dried and the solvent was evaporated. After crystallization from ether, 1.6 g of the expected product melting at 67° C. and after crystallization from isopropanol melting at 73° C. were obtained.

1. customAfter decanting
2. extractionextraction
3. washthe extracts were washed with water
4. customdried
5. customthe solvent was evaporated
6. customAfter crystallization from ether, 1.6 g of the expected product melting at 67° C.
7. customafter crystallization from isopropanol melting at 73° C.
8. customwere obtained