Methyl Bromide → HCID 14406793, compound

HRID 974182Notes

Reaction equation

HRID 974182 reaction equation
O1CCC[CH2:2]1.[CH3:6][CH:7]([CH:25]([CH3:31])[CH2:26][C:27]([CH3:30])([CH3:29])[CH3:28])[CH2:8][N:9]1[CH2:13][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:16][CH:15]=2)[CH:11]([CH3:24])[CH2:10]1.C[Br:33]>C(#N)C>[Br-:33].[CH3:2][N+:9]1([CH2:8][CH:7]([CH3:6])[CH:25]([CH3:31])[CH2:26][C:27]([CH3:28])([CH3:30])[CH3:29])[CH2:13][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([CH3:21])([CH3:22])[CH3:23])=[CH:16][CH:15]=2)[CH:11]([CH3:24])[CH2:10]1

Participants

5

Reactant 3

HCID 6323Methyl BromideHCID 8028TetrahydrofuranHCID 14406792HCID 14406792, compound

Product 1

HCID 14406793HCID 14406793, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

30 g of tetrahydrofuran are added to 40 g of 1-(2,3,5,5-tetramethylhexyl)-3-methyl-4-(p-tert-butyl-phenyl)-pyrrolidine. For the formation of the quaternary salt, 40 g of a solution of methyl bromide in acetonitrile (20% strength) are added. When the mixture stands overnight, the quaternary salt crystallizes out. Filtration with suction gives 20.5 g of product of melting point 250° C. At 270° C., pronounced discoloration occurs.

Workup

  1. customthe quaternary salt crystallizes out
  2. filtrationFiltration with suction

Sources & evidence

ORD record
ord-12504451a20449538b124a40870a057d
Source dataset
uspto-grants-1991_11
Patent number
US05068246

Reaction notes

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