Methyl formate → 4-(2-Aminoethyl)piperazine-1-carbaldehyde

HRID 974189Notes

Reaction equation

HRID 974189 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.[CH:10](OC)=[O:11]>CO>[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH:10]=[O:11])[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 7865Methyl formateHCID 8795Aminoethylpiperazine

Product 1

HCID 148760004-(2-Aminoethyl)piperazine-1-carbaldehydeYield 48.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Corresponding to Example 1, 774.3 g (6.00 mol) of N-2-aminoethylpiperazine in 300 ml of methanol were reacted with 120.0 g (2.00 mol) of methyl formate and 151.6 g (48% of theory) of N-2-aminoethyl-N'-formylpiperazine were obtained at 0.1 mm Hg between 115 and 120° C. in the form of a yellowish liquid

Sources & evidence

ORD record
ord-acb735955c524fed9cd3a5e19811cb42
Source dataset
uspto-grants-1991_11
Patent number
US05068264

Reaction notes

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