反应详情

温度

-10 °C

2.45 g of 4-[3-[ethyl[3-(propylthio)propyl]amino]-2-hydroxypropoxy]-benzonitrile and 1.4 g p-toluenesulfonic acid were mixed in 50 ml of ethanol. The mixture was cooled to -10° C. and 1.7 g of m-chloroperbenzoic acid was added in small protions. The mixture was stirred for 0.5 hour at -10° C. and one hour at room temperature and then evaporated. The residue was dissolved in dichloromethane and washed with three portions of sodium carbonate and twice with water and thereafter dried over sodium sulfate, filtrated and evaporated. The residue, 2.3 g yellow oil, was purified by column chromatography. Yield: 1.4 g of the title compound.

1. customevaporated
2. dissolutionThe residue was dissolved in dichloromethane
3. washwashed with three portions of sodium carbonate and twice with water
4. dry with materialdried over sodium sulfate
5. filtrationfiltrated
6. customevaporated
7. customThe residue, 2.3 g yellow oil, was purified by column chromatography