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HRID974207

反应详情

EQUATION

反应方程式

HRID 974207 的结构方程式

REACTANTS

反应物

3
结构：C#C[Si](C)(C)C
HCID66111

Trimethylsilylacetylene

C5H10Si

结构：CC(C)(C)OC(=O)c1ccccc1Br
HCID3804415

tert-butyl 2-bromobenzoate

C11H13BrO2

结构：ClCCl.O
HCID21908982

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)c1ccc(C#C[Si](C)(C)C)cc1
HCID13965007

tert-Butyl 4-[(trimethylsilyl)ethynyl]benzoate

C16H22O2Si

收率 74%

AUXILIARIES

试剂、催化剂与溶剂

3
结构：Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1
催化剂HCID178418476

未命名化合物

结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

51.4 g of Bromobenzoic acid tert.-butyl ester, 21.6 g of trimethylsilylacetylene, 1.4 g of (Ph3P)2PdCl2 in 400 ml of absolute acetonitrile and 100 ml of triethylamine are stirred under reflux for 8 hours in an atmosphere of nitrogen. After the reaction product has been worked up with CH2Cl2 /H2O and distilled, 40.6 g of 4-(trimethylsilylethinyl)-benzoic acid tert.-butyl ester are obtained.

WORKUP

后处理

  1. temperatureunder reflux for 8 hours in an atmosphere of nitrogen
  2. distillationdistilled