Diethyl Ether → HCID 53675793, compound

HRID 974295Notes

Reaction equation

HRID 974295 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([CH:7]=[CH:8][CH2:9]Cl)=[CH:5][CH:4]=1.[NH2:13][C:14]1[S:15][C:16]2[CH2:17][CH2:18][NH:19][CH2:20][CH2:21][C:22]=2[N:23]=1.C(=O)([O-])[O-].[K+].[K+].CCOCC>C(Cl)(Cl)Cl>[NH2:13][C:14]1[S:15][C:16]2[CH2:17][CH2:18][N:19]([CH2:9][CH:8]=[CH:7][C:6]3[CH:11]=[CH:12][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[CH2:20][CH2:21][C:22]=2[N:23]=1

Participants

6

Reactant 4

HCID 3283Diethyl EtherHCID 11430Potassium CarbonateHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 54508890HCID 54508890, compound

Product 1

HCID 53675793HCID 53675793, compoundYield 10%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 4-methoxy-cinnamyl chloride and 1 equivalent of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in the presence of 1 equivalent of potassium carbonate in chloroform. Yield: 10% of theory, Melting point: 155-160° C. (ether).

Sources & evidence

ORD record
ord-560bef6e872946eebcb3b833a4978577
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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